COSAM » COSAM Faculty » Biological Sciences » Cobine, Paul A.

Paul A. Cobine
Biological Sciences
Associate Professor

Office: 325 Rouse Life Sciences Bldg.

101 Rouse Life Sciences Bldg.
Auburn University, AL 36849

Phone: (334) 844-1661


Postdoctoral Fellow - University of Utah
Ph.D. - The University of Queensland, Australia
B.S. - The University of Queensland, Australia

Research and Teaching Interests

My research is focused on the mechanisms for recruitment and distribution of metals. Metal availability is a limiting factor for cell survival, therefore mechanisms to maintain the appropriate metal concentration have been highly conserved. We are especially interested in 1) how metals are distributed, stored and used in mitochondria; the majority of these studies use the model organism Saccharomyces cerevisiae and 2) the metal requirements of the phytopathogen Xylella fastidiosa in infection and the subsequent development of disease.

Selected Publications

  1. Zhiyuan Ge, James D. Johnson, Paul A. Cobine, Kevin J. McGraw, Rosana Garcia, Geoffrey E. Hill (2015) High Concentrations of Ketocarotenoids in Hepatic Mitochondria of Haemorhous mexicanus. Physiol Biochem Zool. 88:444-450

  2. Jonathan E. Oliver, Paul A. Cobine, Leonardo De La Fuente (2015) Xylella fastidiosa Isolates from Both subsp. multiplex and fastidiosa Cause Disease on Southern Highbush Blueberry (Vaccinium sp.) Under Greenhouse Conditions. Phytopathology. 105:855-862

  3. Hlynialuk CJ, Ling B, Baker ZN, Cobine PA, Yu LD, Boulet A, Wai T, Hossain A, El Zawily AM, McFie PJ, Stone SJ, Diaz F, Moraes CT, Viswanathan D, Petris MJ, Leary SC. (2015) The Mitochondrial Metallochaperone SCO1 Is Required to Sustain Expression of the High-Affinity Copper Transporter CTR1 and Preserve Copper Homeostasis. Cell Rep. pii: S2211-1247(15)00032-7.

  4. Luisa F. Cruz, Jennifer K. Parker, Paul A. Cobine, Leonardo De La Fuente (2014)  Calcium-Enhanced Twitching Motility in Xylella fastidiosa Is Linked to a Single PilY1 Homolog.  Appl Environ Microbiol. 80:7176-7185.

  5. Jonathan E. Oliver, Stephen A. Sefick, Jennifer K. Parker, Travis Arnold, Paul A.  Cobine, Leonardo De La Fuente (2014) Ionome changes in Xylella fastidiosa-infected Nicotiana tabacum correlate with virulence and discriminate between subspecies of bacterial isolates. Mol Plant Microbe Interact. 27:1048-1058. 

  6. Katherine E. Vest, Scot C. Leary, Dennis R. Winge, and Paul A. Cobine (2013) Copper Import into the Mitochondrial Matrix in Saccharomyces cerevisiae is Mediated by Pic2, a Mitochondrial Carrier Family Protein. Journal of Biological Chemistry doi:10.1074/jbc.M113.470674 

  7. Scot C. Leary, Hana Antonicka, Florin Sasarman, Woranontee Weraarpachai, Paul A. Cobine, Min Pan, Garry K. Brown, Ruth Brown, Jacek Majewski, Jeremy Swartzentruber, Shamima Rahman, and Eric Shoubridge  (2013) “Novel mutations in SCO1 as a cause of fatal infantile encephalopathy and lactic acidosis” Human Mutations, 34:1366-1370

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Undergraduate Graduate
General Microbiology - BIOL3200

Last updated: 09/03/2018