COSAM » COSAM Faculty » Biological Sciences » Cobine, Paul A.

Paul A. Cobine
Biological Sciences
Associate Professor

Office: 325 Rouse Life Sciences Bldg.

Address:
101 Rouse Life Sciences Bldg.
Auburn University, AL 36849

Phone: (334) 844-1661
E-Mail: pac0006@auburn.edu

Curriculum vitae

Website


Education

Postdoctoral Fellow - University of Utah
2007
Ph.D. - The University of Queensland, Australia
2004
B.S. - The University of Queensland, Australia
1996


Research and Teaching Interests

My research is focused on the mechanisms for recruitment and distribution of metals. Metal availability is a limiting factor for cell survival, therefore mechanisms to maintain the appropriate metal concentration have been highly conserved. We are especially interested in 1) how metals are distributed, stored and used in mitochondria; the majority of these studies use the model organism Saccharomyces cerevisiae and 2) the metal requirements of the phytopathogen Xylella fastidiosa in infection and the subsequent development of disease.


Selected Publications

Ryan J Weaver, Philip Wang, Geoffrey E Hill, and Paul A. Cobine (2018) An in vivo test of the biologically relevant roles of carotenoids as antioxidants in animals. Journal of Experimental Biology; 221(Pt 15). pii: jeb183665. doi: 10.1242/jeb.183665.
 
Shamima Nasrin, Suresh Ganji, Kavita S. Kakirde, Melissa R. Jacob, Mei Wang, Ranga Rao Ravu, Paul A. Cobine, Ikhlas A. Khan, Cheng-Cang Wu, David A. Mead, Xing-Cong Li, and Mark R. Liles (2018) Chloramphenicol Derivatives with Antibacterial Activity Identified by Functional Metagenomics. Journal of Natural Products; 81(6):1321-1332. doi: 10.1021/acs.jnatprod.7b00903.
 
Qiang Wang, Paul A. Cobine, Jeffrey J. Coleman. (2018) Efficient genome editing in Fusarium oxysporum based on CRISPR/Cas9 ribonucleoprotein complexes. Fungal Genet Biol.;117:21-29. doi: 10.1016/j.fgb.2018.05.003. PMID: 29763675
 
Ryan J. Weaver, Paul A. Cobine, Geoffrey E. Hill (2018) On the bioconversion of dietary carotenoids to astaxanthin in the marine copepod, Tigriopus californicus Journal of Plankton Research, 40(2): 142-150 https://doi.org/10.1093/plankt/fbx072
 
Katherine Mincey, Paul A. Cobine, and Robert S. Boyd. (2018) Nickel hyperaccumulation by Streptanthus polygaloides is associated with herbivory tolerance. Ecological Research, 3(SI): 571-580.
 
Aren Boulet, Katherine E. Vest, Margaret K. Maynard, Micah G. Gammon, Anntionette C. Russell, Alexander T. Mathews, Shelbie E. Cole, Xinyu Zhu, Casey B. Phillips, Jennifer Q. Kwong, Sheel C. Dodani, Scot C. Leary, Paul A. Cobine. (2018) The mammalian phosphate carrier SLC25A3 is a mitochondrial copper transporter required for cytochrome c oxidase biogenesis. Journal of Biological Chemistry. 293(6):1887-1896. pii: jbc.RA117.000265.

Featured as Editor’s choice for top 2% of papers published by JBC
See https://www.eurekalert.org/pub_releases/2018-02/asfb-sfi021418.php
 
Zakery N. Baker, Kimberley Jett, Aren Boulet, AmzadHossain, Paul A. Cobine, Byun-Eun Kim, Amr M.El Zawily, Lee L, Tibbits GF, Micheal J. Petris, Scot C. Leary (2017) The mitochondrial metallochaperone SCO1 maintains CTR1 at the plasma membrane to preserve copper homeostasis in the murine heart. Human Molecular Genetics; 26(23):4617-4628.
 
Zakery N. Baker, Paul A.Cobine, Scot C. Leary. (2017) The mitochondrion: a central architect of copper homeostasis. Metallomics; 9(11):1501-1512.
 
Hongyu Chen, Prem P. Kandel, Luisa F. Cruz, Paul A.Cobine, Leonardo De La Fuente (2017) The Major Outer Membrane Protein MopB Is Required for Twitching Movement and Affects Biofilm Formation and Virulence in Two Xylella fastidiosa strains. Molecular Plant Microbe Interactions;30(11):896-905.
 
Prem P. Kandel, Rodrigo PP. Almeida, Paul A. Cobine, Leonardo De La Fuente. (2017) Natural Competence Rates Are Variable Among Xylella fastidiosa Strains and Homologous Recombination Occurs In Vitro Between Subspecies fastidiosa and multiplex. Molecular Plant Microbe Interactions;30(7):589-600.

 

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Courses

Undergraduate Graduate
General Microbiology - BIOL3200
Clinical Microbiology - BIOL5200
Model Systems and Human Disease - BIOL4970/7970




Last updated: 01/30/2019