COSAM » COSAM Faculty » Physics (ARCHIVED) » Michael Gramlich

Michael Gramlich
Physics
Assistant Professor

Research Areas: Biophysics, Neuroscience, Microscopy

Office: Leach Science Center 3114

Address:
380 Duncan Drive
Auburn, AL 36849

E-Mail: mwg0016@auburn.edu

Website


Education

University of Missouri - Columbia, Ph.D.
2011
University of Missouri - Columbia, B.S.
2005


Professional Employment

Auburn University, Department of Physics, Assistant Professor
2018-Present
Postdoctoral Researcher, Washington University in St. Louis School of Medicine
2015-2018
Postdoctoral Researcher, University of Massachusetts - Amherst
2012-2015


Research and Teaching Interests

My lab focuses on the principles that regulate intra-cellular transport of neuronal resource sharing. First, how do resources, such as synaptic vesicles, navigate the complex road system that supports neurons? There are many road-blocks or defects that inhibit transport, and resources must navigate them quickly. Second, how are resources directed to synapses that need them? Synapses are activated when they communicate with other neurons, and need more resources than non-activated synapses. Third, how do synapses capture and utilize the resources they need? Resources travel quickly to synapses that need them, but must still be captured by synapses before use.



Selected Publications

1.      rTg (TauP301L) 4510 mice exhibit increased VGLUT1 in hippocampal presynaptic glutamatergic vesicles and increased extracellular

          E. Taipala, J.C. Pfitzer, M. Hellums, M.N. Reed, M.W. Gramlich, Front Synaptic Neurosci., 14:925546

 2022

 

2.      Myosin V regulates spatial localization of different forms of neurotransmitter release in central synapses

         D Maschi, MW Gramlich, VA Klyachko Frontiers in Synaptic Neuroscience 13, 650334

 2021

3.      Distinguishing synaptic vesicle precursor navigation of microtubule ends with a single rate constant model

         MW Gramlich, S Balseiro-Gómez, SMA Tabei, M Parkes, S Yogev, Scientific reports 11 (1), 1-11

 2021

4.       Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses

          D Maschi, M Gramlich, V Klyachko, eLife 7, e39440

 2018

5.       Actin/Myosin-V- and Activity-Dependent Inter-synaptic Vesicle Exchange in Central Neurons

           MW Gramlich, VA Klyachko, Cell Reports 18 (9), 2096–2104

2017

6.       Single molecule investigation of kinesin-1 motility using engineered microtubule defects

           MW Gramlich, L Conway, WH Liang, JA Labastide, SJ King, J Xu, JL Ross, Scientific Reports 7, 44290

2017

7.       Activity-Dependence of Synaptic Vesicle Dynamics

          KVA Forte LA, Gramlich MW, J Neuroscience

2017

8.       Fluorescence imaging of nanoscale domains in polymer blends using stochastic optical reconstruction microscopy (STORM)

          MW Gramlich, J Bae, RC Hayward, JL Ross, Optics express 22 (7), 8438-8450

2014

9.       Modern methods to interrogate microtubule dynamics

          M Bailey, L Conway, MW Gramlich, TL Hawkins, JL Ross, Integrative Biology 5 (11), 1324-1333

2013

10.       Microtubule orientation and spacing within bundles is critical for long‐range kinesin‐1 motility

          L Conway, MW Gramlich, SM Ali Tabei, JL Ross, Cytoskeleton 71 (11), 595-610

2014







Last updated: 11/27/2023