COSAM » COSAM Faculty » Physics » Michael Gramlich

Michael Gramlich
Physics
Assistant Professor

Research Areas: Biophysics, Neuroscience, Microscopy

Office: Allison Laboratory #100

E-Mail: mwg0016@auburn.edu

Website


Education

University of Missouri - Columbia, Ph.D.
2011
University of Missouri - Columbia, B.S.
2005


Professional Employment

Auburn University, Department of Physics, Assistant Professor
2018-Present
Postdoctoral Researcher, Washington University in St. Louis School of Medicine
2015-2018
Postdoctoral Researcher, University of Massachusetts - Amherst
2012-2015


Research and Teaching Interests

My lab focuses on the principles that regulate intra-cellular transport of neuronal resource sharing. First, how do resources, such as synaptic vesicles, navigate the complex road system that supports neurons? There are many road-blocks or defects that inhibit transport, and resources must navigate them quickly. Second, how are resources directed to synapses that need them? Synapses are activated when they communicate with other neurons, and need more resources than non-activated synapses. Third, how do synapses capture and utilize the resources they need? Resources travel quickly to synapses that need them, but must still be captured by synapses before use.



Selected Publications

1.       Myosin V functions as a vesicle tether at the plasma membrane to control neurotransmitter release in central synapses

          D Maschi, M Gramlich, V Klyachko, eLife 7, e39440

 2018

2.       Actin/Myosin-V- and Activity-Dependent Inter-synaptic Vesicle Exchange in Central Neurons

           MW Gramlich, VA Klyachko, Cell Reports 18 (9), 2096–2104

2017

3.       Single molecule investigation of kinesin-1 motility using engineered microtubule defects

           MW Gramlich, L Conway, WH Liang, JA Labastide, SJ King, J Xu, JL Ross, Scientific Reports 7, 44290

2017

4.       Activity-Dependence of Synaptic Vesicle Dynamics

          KVA Forte LA, Gramlich MW, J Neuroscience

2017

5.       Fluorescence imaging of nanoscale domains in polymer blends using stochastic optical reconstruction microscopy (STORM)

          MW Gramlich, J Bae, RC Hayward, JL Ross, Optics express 22 (7), 8438-8450

2014

6.       Modern methods to interrogate microtubule dynamics

          M Bailey, L Conway, MW Gramlich, TL Hawkins, JL Ross, Integrative Biology 5 (11), 1324-1333

2013

7.       Critical Role of a Buried Interface in the Stranski-Krastanov Growth of Metallic Nanocrystals: Quantum Size Effects in Ag/Si (111)-(7× 7)

          Y Chen, MW Gramlich, ST Hayden, PF Miceli Physical review letters 114 (3), 035501

2015

8.       Microtubule orientation and spacing within bundles is critical for long‐range kinesin‐1 motility

          L Conway, MW Gramlich, SM Ali Tabei, JL Ross, Cytoskeleton 71 (11), 595-610

2014







Last updated: 12/15/2018