Selected Publications

    2017
  • Li Y, Rong Y, Bao L, Nie B, Ren G, Zheng C, Amin R, Arnold RD, Babu JR, Huggins KW. Suppression of adipocyte differentiation and lipid accumulation by stearidonic acid (SDA) in 3T3-L1 cells. Lipids in Health and Disease 2017;16:181-191.

  • Kothari V, Luo Y, Tornabene T, O'Neill AM, Greene MW, Geetha T, Babu JR. High fat diet induces brain insulin resistance and cognitive impairement in mice. Biochim Biophys Acta 2017;1863:499-508.

  • Rege SD, Geetha T, Broderick TL, Babu JR. Can diet and physical activity limit Alzheimer's disease risk? Current Alzheimer Research 2017;14:76-93.

  • 2016
  • Neidert LE, Waninright KS, Zheng C, Babu JR, Kluess HA. Plasma dipeptidyl peptidase IV activity and measures of body composition in apparently healthy people. Heliyon 2016; 2:e00097. doi:10.1016/j.heliyon.2016.e00097.

  • Wilson DN, Schacht SE, Nakkash LA, Babu JR, Broderick TL. Resveratrol prevents pulmonary trunk remodeling but not right ventricular hypertrophy in monocrotaline- induced pulmonary hypertension. Pathophysiology 2016: May.27. doi:10.1016/j.pathophys.2016.05.004

  • 2015
  • Zheng C, Geetha T, Gearing M, Babu JR. Amyloid beta abrogated TrkA ubiquitination in PC12 cells analogous to Alzheimer's disease. Journal of Neurochemistry 2015;6:919-925.

  • Rege SD, Geetha T, Broderick TL, Babu JR. Resveratrol Protects beta amyloid-Induced Oxidative Damage and Memory Associated Proteins in H19-7 Hippocampal Neuronal Cells. Current Alzheimer Research 2015;12(2):147-156.

  • Pondugula SR, Flannery PC, Apte U, Babu JR, Geetha T, Rege SD, Chen T, Abbott KL. PPM1A phosphatase is involved in regulating PXR-mediated CYP3A4 gene expression. Drug Metabolism and Disposition 2015;3:385-391.

  • 2014
  • Zheng C, Geetha T, Babu JR. Failure of ubiquitin proteasome system: Risk for neurodegenerative diseases. Neurodegenerative Diseases 2014;14:161-175.

  • Brust KB, Corbell KA, Al-Nakkash L, Babu JR, Broderick TL. Expression of gluconeogenic enzymes and 11beta-HSD type 1 in liver of diabetic mice after acute exercise. Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy 2014;7:495-504.

  • Rege SD, Geetha T, Griffin GD, Broderick TL, Babu JR. Neuroprotective effects of resveratrol in Alzheimer disease pathology. Frontiers in Aging Neuroscience 2014: doi: 10.3389/fnagi.2014.00218.

  • Desai G, Zheng C, Geetha T, Mathews ST, White BD, Huggins KW, Zizza CA, Broderick TL, Babu JR. The pancreas-brain axis: insight into disrupted mechanisms associating type 2 diabetes and Alzheimer disease. Journal of Alzheimer's Disease 2014;42:347-356.

  • 2013
  • Rege SD, Kumar S, Wilson D, Tamura L, Geetha T, Mathews ST, Huggins KW, Broderick TL, Babu JR. Resveratrol protects the brain of obese mice from oxidative damage. Oxidative Medicine and Cellular Longevity 2013; 2013: 419092.doi: 10.1155/2013/419092.

  • Geetha T, Rege SD, Mathews SE, Meakin SO, White MF, Babu JR. Nerve growth factor Receptor TrKA, a new receptor in insulin signaling pathway in PC12 cells. Journal of Biological Chemistry 2013; 288: 23807-23813.

  • Rege SD, Geetha T, Pondugula S, Zizza C, Wernette C, Babu JR. Non-coding RNAs in Neurodegenerative Diseases. ISRN Neurology 2013 Apr 30; 2013:375852. doi: 10.1155/2013/375852. 2012; 287:29672-29678.

  • 2012
  • Geetha T, Zheng C, McGregor WC, White DB, Diaz-Meco MT, Babu JR. TRAF6 and p62 inhibit amyloid beta-induced neuronal death through p75 neurotrophin receptor. Neurochemistry International 2012; 61: 1289-1293. 2012; 421:286-290.

  • Geetha T, Zheng C, Vishwaprakash N, Broderick TL, Babu JR. Sequestosome 1/p62, a scaffolding protein, is a newly identified partner of IRS-1. Journal of Biological Chemistry 2012; 287: 29672-29678.

  • Geetha T, Zheng C, Unroe B, Sycheva M, Kluess H, Babu JR. Polyubiquitination of the neurotrophin receptor p75 directs neuronal cell survival. Biochemical and Biophysical Research Communications. 2012; 421: 286-290.

  • Geetha T, Vishwaprakash N, Sycheva M, Babu JR. Sequestosome 1/p62: Across diseases.Biomarkers. 2012; 17: 99-103.

  • Published before 2012
  • Diarra A, Geetha T, Potter P, Babu JR. Signaling of the neurotrophin receptor p75 in relation to Alzheimer's Disease. Biochemical and Biophysical Research Communications. 2009; 390: 352-356.

  • Babu JR, Seibenhener ML, Peng J, Stroem AL, Kemppainen R, Cox N, Zhu H, Wooten M, Diaz-Meco MT, Moscat J. Wooten MW. Genetic inactivation of p62 leads to accumulation of hyperphosphorylated tau and neurodegeneration. Journal of Neurochemistry 2008; 106: 107-120.

  • Wooten MW, Geetha T, Babu JR, Seibenhener ML, Peng J, Cox N, Diaz-Meco MT, Moscat J. Essential role of SQSTM1/p62 in regulating accumulation of K63-ubiquitinated proteins. Journal of Biological Chemistry. 2008; 283: 6783-6789.

  • Zhou X#, Babu JR#, Silva S, Shu Q, Graef I, Oliver T, Tomoda T, Tani T, Wooten MW, and Wang, F. Unc-51-like kinase ½- mediated endocytic process regulate NGF signaling and filopodia extension in sensory axons. Proceedings of the National Academy of sciences 2007; 104: 5842-5847. (# Equal Contribution)

  • Wooten MW, Hu X, Babu JR, Seibenhener, ML, Geetha T, Paine MG, and Wooten MC. Signaling, polyubiquitination, trafficking, and inclusions: sequestosome 1/p62's role in neurodegenerative disease. Journal of Biomedicine and Biotechnology 2006; 62079-62096. (Invited Review Article - 18 pages)

  • Paine MG, Babu JR, Seibenhener ML, and Wooten MW. Evidence for p62 aggregate formation: role in cell survival. FEBS Letters 2005; 579: 5029-5034.

  • Wooten MW, Geetha T, Seibenhener ML, Babu JR, Diaz-Meco MT, and Moscat J. The p62 scaffold regulates nerve growth factor-induced NF-kappa B activation by influencing TRAF6 polyubiquitination. Journal of Biological Chemistry 2005; 280: 35625-35629.

  • Babu JR, Geetha T, Wooten MW. Sequestosome 1/p62 shuttles polyubiquitinated tau for proteasomal degradation. Journal of Neurochemistry 2005; 94: 192-203.

  • Seibenhener ML, Babu JR, Geetha T, Wong H, Krishna NR, Wooten MW. Sequestosome/p62 is a polyubiquitin chain binding protein involved in ubiquitin proteasomal degradation. Molecular and Cellular Biology 2004; 24: 8055-8068.

  • Babu JR, Jeganathan KB, Baker DJ, Wu X, Kang-Decker N, van Deursen JM. Rae1 is an essential checkpoint regulator that cooperates with Bub3 to prevent missegregation. Journal of Cell Biology 2003; 160: 341-353.
    Editorial text http://www.jcb.org/cgi/content/full/160/3/284-a

  • Wang X, Babu JR, Harden JM, Jablonski SA, Gazi MH, Lingle WL, de Groen PC, Yen TJ, van Deursen JM. The mitotic checkpoint protein hBUB3 and the mRNA export factor hRAE1 interact with GLE2p-binding sequence (GLEBS)-containing proteins. Journal of Biological Chemistry 2001; 276: 26559-26567.

Publications in the name of Jeganathan Ramesh Babu