Department of Chemistry and Biochemistry
Assistant Professor
Research Areas: Biochemistry
Office: 266 Chemistry Building
Address:
179 Chemistry Building
Auburn, AL 36849
Phone: (334) 844-6908
Email: kwrush@auburn.edu
Research: Metalloenzymology | Bioinorganic Chemistry | X-ray spectroscopy
We are interested in metalloenzyme catalysis and spectroscopic characterization of catalytic intermediates in order to yield insights into the molecular basis of biological phenomena. The enzyme systems we are currently studying are crucial to thyroid hormone homeostasis, oxygen activation and intracellular redox balance, and biosynthesis of antimicrobial natural products. Selenium-containing amino acids are a particular interest in our laboratory, which we aim to use as a labelling tool for element-specific spectroscopic characterization and understand their functionality within biological catalysis.
We use a variety of biochemical (heterologous protein expression, SDS-PAGE and Western blot analysis, enzyme functional assays), analytical (ICP-OES, protein chromatography, LC-MS), and spectroscopic (UV-visible, infrared, and X-ray absorption) techniques. A primary focus in our lab is applying X-ray absorption spectroscopy (XAS) and emerging XAS high resolution techniques to seleno- and metalloprotein systems relevant to human health.
Teaching: BCHE 7270 – Biochemical Research Techniques
Last updated: 03/20/2024